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Enzalutamide carboxylic acid

CAS No. 1242137-15-0

Enzalutamide carboxylic acid( —— )

Catalog No. M21564 CAS No. 1242137-15-0

Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Enzalutamide carboxylic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
  • Description
    Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
  • In Vitro
    Enzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    Androgen Receptor
  • Research Area
    cancer
  • Indication
    castration-resistant prostate cancer

Chemical Information

  • CAS Number
    1242137-15-0
  • Formula Weight
    451.4
  • Molecular Formula
    C20H13F4N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (276.92 mM)
  • SMILES
    CC1(C)N(C(=S)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F)c1ccc(C(O)=O)c(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.van Nuland M et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.
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