Cart
sales@molnova.com
Enzalutamide carboxylic acid
CAS No. 1242137-15-0
Enzalutamide carboxylic acid( —— )
Catalog No. M21564 CAS No. 1242137-15-0
Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 77 | Get Quote |
|
| 5MG | 115 | Get Quote |
|
| 10MG | 177 | Get Quote |
|
| 25MG | 299 | Get Quote |
|
| 50MG | 417 | Get Quote |
|
| 100MG | 615 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameEnzalutamide carboxylic acid
-
NoteResearch use only, not for human use.
-
Brief DescriptionEnzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
-
DescriptionEnzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
-
In VitroEnzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive.
-
In Vivo——
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetAndrogen Receptor (AR)
-
RecptorAndrogen Receptor
-
Research Areacancer
-
Indicationcastration-resistant prostate cancer
Chemical Information
-
CAS Number1242137-15-0
-
Formula Weight451.4
-
Molecular FormulaC20H13F4N3O3S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (276.92 mM)
-
SMILESCC1(C)N(C(=S)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F)c1ccc(C(O)=O)c(F)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.van Nuland M et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.
molnova catalog
related products
-
Dimethylcurcumin
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.Dimethylcurcumin is able to degrade fAR and AR3 in a dose-dependent manner in various human PCa cells. Dimethylcurcumin can also effectively suppress AR-targeted genes in CWR22Rv1-fARKD cells.
-
UT-155
UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).
-
BMS-641988
BMS-641988 is a potent, selective, nonsteroidal androgen receptor antagonist with Ki of 1.7 nM, MDA-MB-453 cell IC50 of 16 nM.
